The good news is that there apparently is a lot of research being done to manufacture drugs for IBS. I imagine, with all of the suffering out there, there is a lot of money to be made by these companies. The bad news is that for me, none of them help, and actually make me feel worse. I honestly could not give the new pill for IBS/C, Linzess, a fair trial of at least a week. I found the mechanism of the pill so forceful (it kind of has to be to make the body”go”), that it caused my beleaguered system to have a very strong reaction. Life is tenuous and uncomfortable enough for me without making it worse. Now some might say, if one gave it a chance, then the body might adjust. While this may be true (though I doubt it), I lack the ability and fortitude to do so. Perhaps if I was staying in a facility with nothing to do but try these meds and no “real life” to intercede, I might be able to give these new meds a fair shake when they come out. But I live in the real life, and it’s very hard to navigate that with scary symptoms. After all these years, sometimes I feel the devil I know is better than the unknown, probably more violent devil in these meds. I am burned out and need a gentler path. Since everyone’s systems are different, I have no doubt that some people might experience a benefit from taking Linzess. I can only say that at this point, a “magic bullet” in the form of a pill from a pharmaceutical company, is not a viable option for my problem, or my psyche.